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Reactive Oxygen Species: Rhodamine‐Modified Upconversion Nanophosphors for Ratiometric Detection of Hypochlorous Acid in Aqueous Solution and Living Cells (Small 17/2014)
Author(s) -
Zhou Yi,
Pei Wenbo,
Wang Chenyuan,
Zhu Jixin,
Wu Jiansheng,
Yan Qinyu,
Huang Ling,
Huang Wei,
Yao Cheng,
Loo Joachim Say Chye,
Zhang Qichun
Publication year - 2014
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201470106
Subject(s) - hypochlorous acid , reactive oxygen species , aqueous solution , photon upconversion , myeloperoxidase , chemistry , photochemistry , nanosensor , oxygen , nanotechnology , ion , materials science , biochemistry , organic chemistry , inflammation , biology , immunology
Hypochlorous acid (HOCl), a reactive oxygen species (ROS) produced by myeloperoxidase (MPO) enzyme‐mediated peroxidation of chloride ions, acts as a critical microbicidal agent in response to inflammatory stimuli. As reported by J. S. C. Loo, Q. C. Zhang, and co‐workers on page 3560, a water‐soluble nano detection system using rhodaminemodified upconversion nanophosphor is developed for ratiometric UCL imaging of HOCl in living cells, which could provide a novel next‐generation imaging technique for bio‐imaging HOCl in living systems without background noise.