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Gene Organization: Nano‐Dissection and Sequencing of DNA at Single Sub‐Nuclear Structures (Small 16/2014)
Author(s) -
Chen Brandon K.,
Anchel David,
Gong Zheng,
Cotton Rachel,
Li Ren,
Sun Yu,
BazettJones David P
Publication year - 2014
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201470097
Subject(s) - nano , nanotechnology , dna , dna sequencing , dissection (medical) , materials science , computational biology , genetics , biology , anatomy , composite material
A technique for extracting DNA from a cell nucleus is reported by Y. Sun, D. P. Bazett‐Jones, and co‐workers. The nano‐dissection tool is shown above the specimen in a scanning electron microscope image before and after DNA extraction. On page 3267, extracted DNA is then identified by sequencing. Regions of interest identified by fluorescence microscopy are determined by correlative imaging and are precisely manipulated.