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Zwitterionic Coatings: Zwitterionic‐Coated “Stealth” Nanoparticles for Biomedical Applications: Recent Advances in Countering Biomolecular Corona Formation and Uptake by the Mononuclear Phagocyte System (Small 13/2014)
Author(s) -
García Karina Pombo,
Zarschler Kristof,
Barbaro Lisa,
Barreto José A.,
O'Malley William,
Spiccia Leone,
Stephan Holger,
Graham Bim
Publication year - 2014
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201470074
Subject(s) - mononuclear phagocyte system , nanomedicine , nanotechnology , nanoparticle , phagocyte , nanotoxicology , materials science , chemistry , phagocytosis , biology , microbiology and biotechnology , immunology
The development of nanoparticle assemblies for in vivo applications is hampered by the fact that most nanoparticles are scavenged by the mononuclear phagocyte system, in a process commencing with the rapid adsorption of serum proteins, including antibodies, to their surface. On page 2516, L. Spiccia, H. Stephan, B. Graham, and colleagues summarize the recent efforts to develop zwitterionic‐coatings, which resist the formation of such a “biomolecular corona”, providing promising platforms for future nanomedicine design.