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Metallofullerenols: Polyhydroxylated Metallofullerenols Stimulate IL‐1β Secretion of Macrophage through TLRs/MyD88/NF‐κB Pathway and NLRP 3 Inflammasome Activation (Small 12/2014)
Author(s) -
Chen Zhiyun,
Liu Ying,
Sun Baoyun,
Li Han,
Dong Jinquan,
Zhang Lijuan,
Wang Liming,
Wang Peng,
Zhao Yuliang,
Chen Chunying
Publication year - 2014
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201470069
Subject(s) - inflammasome , secretion , microbiology and biotechnology , macrophage , signal transduction , chemistry , nf κb , inflammation , biology , immunology , biochemistry , in vitro
Metallofullerenols uptaken by macrophages can promote the production of inflammatory cytokines like IL‐1β by triggering two signaling pathways indepentently. As reported on page 2362 by C. Chen and co‐workers, fullerenols prime macrophages to express pro‐IL‐1β viaTLRs/MyD88 pathway and subsequently activate NF‐κB. Importantly, they activate NLRP 3 inflammasome in macrophages, which is required for processing pro‐IL‐1β into mature IL‐1β. These findings contibute to better understanding their underlying mechanism of antitumor chemotherapeutics and good immunoregulatory effects.