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Plasmonic Nanostars: In Vivo Volumetric Photoacoustic Molecular Angiography and Therapeutic Monitoring with Targeted Plasmonic Nanostars (Small 8/2014)
Author(s) -
Nie Liming,
Wang Shouju,
Wang Xiaoyong,
Rong Pengfei,
Ma Ying,
Liu Gang,
Huang Peng,
Lu Guangming,
Chen Xiaoyuan
Publication year - 2014
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201470044
Subject(s) - photoacoustic imaging in biomedicine , photothermal therapy , materials science , in vivo , plasmon , nanotechnology , conjugated system , surface plasmon resonance , biomedical engineering , cancer research , biophysics , nanoparticle , medicine , optics , polymer , optoelectronics , biology , physics , microbiology and biotechnology , composite material
Induced angiogenesis is a major hallmark of malignant tumor. As reported on page 1585, G. Lu, X. Chen, and co‐workers design cyclic Arg‐Gly‐Asp (RGD) peptide conjugated plasmonic gold nanostars (RGD‐GNS) to specifically target integrin avß3 overxpressed on tumor neovasculature. Quantitative volumetric angiography of tumors can be achieved with high resolution and deep penetration by a hemispherical photoacoustic imaging system. It also permits photothermal therapy and sequential therapeutic monitoring.