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Graphene Oxide: Photothermally Controlled Gene Delivery by Reduced Graphene Oxide–Polyethylenimine Nanocomposite (Small 1/2014)
Author(s) -
Kim Hyunwoo,
Kim Won Jong
Publication year - 2014
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201470008
Subject(s) - graphene , polyethylenimine , oxide , nanocomposite , materials science , nanotechnology , gene delivery , chemistry , gene , genetic enhancement , biochemistry , transfection , metallurgy
An external‐stimuli‐triggered and spatially and temporally controlled gene delivery vehicle is constructed by H. Kim and W. J. Kim using a functionalized reduced graphene oxide (rGO)‐based nanocomposite. Upon light irradiation, the vehicle generates local heat, causing the accelearated endosomal escape of polyplexes. This platform, described in detail on page 117 , makes it possible to develop a photothermally controlled gene carrier with maximized therapeutic efficacy and high spatial/temporal control.