Graphene Oxide: Photothermally Controlled Gene Delivery by Reduced Graphene Oxide–Polyethylenimine Nanocomposite (Small 1/2014) | Zendy

Kim Hyunwoo | Zendy; Kim Won Jong | Zendy

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Graphene Oxide: Photothermally Controlled Gene Delivery by Reduced Graphene Oxide–Polyethylenimine Nanocomposite (Small 1/2014)

Author(s) -

Kim Hyunwoo,

Kim Won Jong

Publication year - 2014

Publication title -

small

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.785

H-Index - 236

eISSN - 1613-6829

pISSN - 1613-6810

DOI - 10.1002/smll.201470008

Subject(s) - graphene , polyethylenimine , oxide , nanocomposite , materials science , nanotechnology , gene delivery , chemistry , gene , genetic enhancement , biochemistry , transfection , metallurgy

An external‐stimuli‐triggered and spatially and temporally controlled gene delivery vehicle is constructed by H. Kim and W. J. Kim using a functionalized reduced graphene oxide (rGO)‐based nanocomposite. Upon light irradiation, the vehicle generates local heat, causing the accelearated endosomal escape of polyplexes. This platform, described in detail on page 117 , makes it possible to develop a photothermally controlled gene carrier with maximized therapeutic efficacy and high spatial/temporal control.

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