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Shape‐Dependent Targeting of Injured Blood Vessels by Peptide Amphiphile Supramolecular Nanostructures
Author(s) -
Moyer Tyson J.,
Kassam Hussein A.,
Bahnson Edward S. M.,
Morgan Courtney E.,
Tantakitti Faifan,
Chew Teng L.,
Kibbe Melina R.,
Stupp Samuel I.
Publication year - 2015
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201403429
Subject(s) - supramolecular chemistry , amphiphile , nanostructure , nanofiber , nanotechnology , tracking (education) , materials science , peptide , intervention (counseling) , computer science , medicine , chemistry , biochemistry , psychology , molecule , copolymer , organic chemistry , composite material , pedagogy , psychiatry , polymer
Targeting of vascular intervention by systemically delivered supramolecular nanofibers after balloon angioplasty is described. Tracking of self‐assembling peptide amphiphiles using fluorescence shows selective binding to the site of vascular intervention. Cylindrical nanostructures are observed to target the site of arterial injury, while spherical nanostructures with an equivalent diameter display no binding.