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Electrokinetic Preconcentration of Small Molecules Within Volumetric Electromagnetic Hotspots in Surface Enhanced Raman Scattering
Author(s) -
Park Moonseong,
Oh YoungJae,
Park SangGil,
Yang SeungBum,
Jeong KiHun
Publication year - 2015
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201402942
Subject(s) - raman scattering , electrokinetic phenomena , molecule , materials science , raman spectroscopy , nanotechnology , scattering , analytical chemistry (journal) , chemistry , optics , chromatography , physics , organic chemistry
The on‐chip integration of a preconcentration chamber for ultrasensitive surface‐enhanced Raman scattering (SERS) is shown. Small molecules are preconcentrated using 3D volumetric electromagnetic hotspots. The experimental results demonstrate an enhancement of the SERS signals of over two orders of magnitude, which allows the fingerprinting of neurotransmitter molecules at the nanomolar level and furthers the selective detection of oppositely charged molecules. This on‐chip integration will provide new directions for ultrasensitive SERS applications.