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Silica Nanopills for Targeted Anticancer Drug Delivery
Author(s) -
Alba María,
Delalat Bahman,
Formentín Pilar,
Rogers MaryLouise,
Marsal Lluís F.,
Voelcker Nicolas H.
Publication year - 2015
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201402930
Subject(s) - targeted drug delivery , nanotechnology , drug delivery , drug , conjugated system , anticancer drug , materials science , neuroblastoma , cancer cell , chemistry , cancer , cell culture , pharmacology , medicine , biology , polymer , composite material , genetics
Multifunctional SiO 2 microtubes for targeted drug delivery are produced with precise control over shape and size by combining lithography and electrochemical etching. The hollow core is loaded with a lipophilic anticancer drug generating nanopills and an antibody is conjugated to the external surface for cancer cell targeting. Results demonstrate selective killing of neuroblastoma cells that express the cognate receptor.