Premium
Inhibiting EGFR Clustering and Cell Proliferation with Gold Nanoparticles
Author(s) -
Paviolo Chiara,
Chon James W. M.,
Clayton Andrew H. A.
Publication year - 2015
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201402701
Subject(s) - hela , colloidal gold , receptor , epidermal growth factor , nanoparticle , epidermal growth factor receptor , nanotechnology , biophysics , cell , cell growth , microbiology and biotechnology , materials science , chemistry , biochemistry , biology
Gold nanoparticles are functionalized with epidermal growth factor (EGF) molecules and incubated with HeLa cells. These new complexes mechanically interfere with the activation of EGF receptors in a length‐dependent manner. Protein‐functionalized gold nanoparticles hold great potential for unveiling the fundamental characteristics of cell receptors and for future pharmacological studies on receptor targeting.