Premium
Supramolecular Nanosubstrate‐Mediated Delivery for Reprogramming and Transdifferentiation of Mammalian Cells
Author(s) -
Hou Shuang,
Choi Jinsil,
Chen KuanJu,
Zhang Yang,
Peng Jinliang,
Garcia Mitch A.,
Yu JueHua,
ThakoreShah Kaushali,
Ro Tracy,
Chen JieFu,
Peyda Parham,
Fan Guoping,
Pyle April D.,
Wang Hao,
Tseng HsianRong
Publication year - 2015
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201402602
Subject(s) - reprogramming , transdifferentiation , supramolecular chemistry , nanotechnology , induced pluripotent stem cell , substrate (aquarium) , materials science , chemistry , microbiology and biotechnology , cell , biology , biochemistry , molecule , organic chemistry , embryonic stem cell , gene , ecology
Supramolecular nanosubstrate‐mediated delivery (SNSMD) leverages the power of molecular self‐assembly and a nanostructured substrate platform for the low toxicity, highly efficient co‐delivery of biological factors encapsulated in a nanovector. Human fibroblasts are successfully reprogrammed into induced pluripotent stems and transdifferentiated into induced neuronal‐like cells.