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Biodegradable Nanoellipsoidal Artificial Antigen Presenting Cells for Antigen Specific T‐Cell Activation
Author(s) -
Meyer Randall A.,
Sunshine Joel C.,
Perica Karlo,
Kosmides Alyssa K.,
Aje Kent,
Schneck Jonathan P.,
Green Jordan J.
Publication year - 2015
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201402369
Subject(s) - antigen , immune system , antigen presenting cell , materials science , cell , ellipsoid , microbiology and biotechnology , t cell , artificial cell , biophysics , chemistry , immunology , biology , biochemistry , physics , membrane , astronomy
Non‐spherical nanodimensional artificial antigen presenting cells (naAPCs) offer the potential to systemically induce an effective antigen‐specific immune response. In this report it is shown biodegradable ellipsoidal naAPCs mimic the T‐Cell/APC interaction better than equivalent spherical naAPCs. In addition, it is demonstrated ellipsoidal naAPCs offer reduced non‐specific cellular uptake and a superior pharmacokinetic profile compared to spherical naAPCs.