Premium
A Pillararene‐Based Ternary Drug‐Delivery System with Photocontrolled Anticancer Drug Release
Author(s) -
Yu Guocan,
Yu Wei,
Mao Zhengwei,
Gao Changyou,
Huang Feihe
Publication year - 2015
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201402236
Subject(s) - prodrug , drug delivery , drug , computer science , combinatorial chemistry , chemistry , ethylene glycol , nanotechnology , materials science , organic chemistry , pharmacology , medicine , biochemistry
A novel ternary drug delivery system (DDS) is constructed using a photodegradable anticancer prodrug ( Py‐Cbl ), a water‐soluble pillararene supramolecular container ( WP6 ), and the diblock copolymer methoxy‐poly(ethylene glycol) 114 ‐ block ‐poly( L ‐lysine hydrochloride) 200 . This DDS successfully addresses three important issues: enhancement of the water solubility of the anticancer prodrug; controlled release of the anticancer drug; accurate and quantitative measurement of the drug release.