A Pillararene‐Based Ternary Drug‐Delivery System with Photocontrolled Anticancer Drug Release | Zendy

Yu Guocan | Zendy; Yu Wei | Zendy; Mao Zhengwei | Zendy; Gao Changyou | Zendy; Huang Feihe | Zendy

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A Pillararene‐Based Ternary Drug‐Delivery System with Photocontrolled Anticancer Drug Release

Author(s) -

Yu Guocan,

Yu Wei,

Mao Zhengwei,

Gao Changyou,

Huang Feihe

Publication year - 2015

Publication title -

small

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.785

H-Index - 236

eISSN - 1613-6829

pISSN - 1613-6810

DOI - 10.1002/smll.201402236

Subject(s) - prodrug , drug delivery , drug , computer science , combinatorial chemistry , chemistry , ethylene glycol , nanotechnology , materials science , organic chemistry , pharmacology , medicine , biochemistry

A novel ternary drug delivery system (DDS) is constructed using a photodegradable anticancer prodrug ( Py‐Cbl ), a water‐soluble pillararene supramolecular container ( WP6 ), and the diblock copolymer methoxy‐poly(ethylene glycol) 114 ‐ block ‐poly( L ‐lysine hydrochloride) 200 . This DDS successfully addresses three important issues: enhancement of the water solubility of the anticancer prodrug; controlled release of the anticancer drug; accurate and quantitative measurement of the drug release.

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