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Superparamagnetic Iron Oxide Nanoparticle Micelles Stabilized by Recombinant Oleosin for Targeted Magnetic Resonance Imaging
Author(s) -
Vargo Kevin B.,
Zaki Ajlan Al,
WardenRothman Robert,
Tsourkas Andrew,
Hammer Daniel A.
Publication year - 2015
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201402017
Subject(s) - oleosin , superparamagnetism , recombinant dna , micelle , nanoparticle , iron oxide , nanotechnology , materials science , iron oxide nanoparticles , magnetic nanoparticles , chemistry , biophysics , biochemistry , organic chemistry , magnetization , biology , physics , quantum mechanics , aqueous solution , magnetic field , metallurgy , gene
Recombinant surfactants present a new platform for stabilizing and targeting nanoparticle imaging agents. Superparamagnetic iron oxide nanoparticle‐loaded micelles for MRI contrast are stabilized by an engineered variant of the naturally occurring protein oleosin and targeted using a Her2/neu affibody‐oleosin fusion. The recombinant oleosin platform allows simple targeting and the ability to easily swap the ligand for numerous targets.