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Efficient Encapsulation of Fe 3 O 4 Nanoparticles into Genetically Engineered Hepatitis B Core Virus‐Like Particles Through a Specific Interaction for Potential Bioapplications
Author(s) -
Shen Lihua,
Zhou Jun,
Wang Yixiao,
Kang Ning,
Ke Xuebin,
Bi Shengli,
Ren Lei
Publication year - 2015
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201401952
Subject(s) - nitrilotriacetic acid , biocompatibility , nanoparticle , materials science , nanotechnology , magnetic nanoparticles , drug delivery , nanobiotechnology , chelation , metallurgy
Self‐assembly of viral coating proteins encapsulating functional nanoparticles provides a new class of biomaterials with robust chemical and physical properties for potential applications in functional imaging, and therapeutic or diagnostic agent delivery. Herein, a straightforward method is demonstrated for efficient encapsidation of magnetic nanoparticles into the engineered virus‐like particle (VLP) through the affinity of histidine tags for the nickel‐ nitrilotriacetic acid (NTA) chelate. Monodispersed, uniformly sized, magnetic core‐containing VLPs are obtained at high efficiency (>85%) and used as the cellular T 2 contrast agents for MR imaging applications thanks to their biocompatibility, higher cellular uptake, as well as higher r 2 values.