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A Multifunctional Nanoplatform for Imaging, Radiotherapy, and the Prediction of Therapeutic Response
Author(s) -
McQuade Casey,
Al Zaki Ajlan,
Desai Yaanik,
Vido Michael,
Sakhuja Timothy,
Cheng Zhiliang,
Hickey Robert J.,
Joh Daniel,
Park SoJung,
Kao Gary,
Dorsey Jay F.,
Tsourkas Andrew
Publication year - 2015
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201401927
Subject(s) - magnetic resonance imaging , radiation therapy , colloidal gold , materials science , iron oxide nanoparticles , nanoparticle , contrast enhancement , irradiation , superparamagnetism , biocompatible material , biomedical engineering , nanotechnology , medicine , radiology , physics , nuclear physics , magnetization , quantum mechanics , magnetic field
Gold nanoparticles have garnered interest as both radiosensitzers and computed tomography (CT) contrast agents. However, the extremely high concentrations of gold required to generate CT contrast is far beyond that needed for meaningful radiosensitization, which limits their use as combined therapeutic–diagnostic (theranostic) agents. To establish a theranostic nanoplatform with well‐aligned radiotherapeutic and diagnostic properties for better integration into standard radiation therapy practice, a gold‐ and superparamagnetic iron oxide nanoparticle (SPION)‐loaded micelle (GSM) is developed. Intravenous injection of GSMs into tumor‐bearing mice led to selective tumoral accumulation, enabling magnetic resonance (MR) imaging of tumor margins. Subsequent irradiation leads to a 90‐day survival of 71% in GSM‐treated mice, compared with 25% for irradiation‐only mice. Furthermore, measurements of the GSM‐enhanced MR contrast are highly predictive of tumor response. Therefore, GSMs may not only guide and enhance the efficacy of radiation therapy, but may allow patients to be managed more effectively.