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Trajectory‐Based Co‐Localization Measures for Nanoparticle‐Cell Interaction Studies
Author(s) -
Varela Juan A.,
Åberg Christoffer,
Simpson Jeremy C.,
Dawson Kenneth A.
Publication year - 2015
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201401849
Subject(s) - nanoparticle , nanotechnology , trajectory , materials science , biological system , physics , biology , astronomy
High‐resolution live cell microscopy will soon have a fundamental role in understanding bio‐nano interactions, providing material that can be exploited using single particle tracking techniques. The present work uses 3D timelapse images obtained with confocal microscopy, to temporally resolve the co‐localization between polystyrene nanoparticles and lysosomes in live cells through object‐based measurements.