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Mesoporous Silica Supraparticles for Sustained Inner‐Ear Drug Delivery
Author(s) -
Wang Yajun,
Wise Andrew K.,
Tan Justin,
Maina James W.,
Shepherd Robert K.,
Caruso Frank
Publication year - 2014
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201401767
Subject(s) - mesoporous silica , drug delivery , materials science , mesoporous material , nanotechnology , in vivo , nanoparticle , inner ear , chemistry , medicine , anatomy , microbiology and biotechnology , biology , catalysis , biochemistry
Mesoporous silica supraparticles (MS‐SPs) are prepared via self‐assembly of mesoporous silica nanoparticles under capillary force action in confined droplets. The MS‐SPs are effective carriers for sustained drug delivery. Animal studies show that these particles are suitable for chronic intracochlear implantation, and neurotrophins released from the MS‐SPs can efficiently rescue primary auditory neurons in an in vivo sensorineural hearing loss model.