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Enhanced Two‐Photon Fluorescence Imaging and Therapy of Cancer Cells via Gold@Bridged Silsesquioxane Nanoparticles
Author(s) -
Croissant Jonas,
Maynadier Marie,
Mongin Olivier,
Hugues Vincent,
BlanchardDesce Mireille,
Chaix Arnaud,
Cattoën Xavier,
Wong Chi Man Michel,
Gallud Audrey,
GaryBobo Magali,
Garcia Marcel,
Raehm Laurence,
Durand JeanOlivier
Publication year - 2015
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201401759
Subject(s) - photosensitizer , silsesquioxane , colloidal gold , photodynamic therapy , two photon excitation microscopy , nanoparticle , fluorescence , materials science , photochemistry , fluorescence lifetime imaging microscopy , nanotechnology , chemistry , optics , organic chemistry , polymer , physics , composite material
A two‐photon photosensitizer with four triethoxysilyl groups is synthesized through the click reaction. This photosensitizer allows the design of bridged silsesquioxane (BS) nanoparticles through a sol–gel process; moreover, gold core BS shells or BS nanoparticles decorated with gold nanospheres are synthesized. An enhancement of the two‐photon properties is noted with gold and the nanoparticles are efficient for two‐photon imaging and two‐photon photodynamic therapy of cancer cells.