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ZnO Nanowire Arrays Exhibit Cytotoxic Distinction to Cancer Cells with Different Surface Charge Density: Cytotoxicity is Charge‐Dependent
Author(s) -
Ning Ruizhi,
Wang Shiqi,
Wu Jing,
Wang Feng,
Lin JinMing
Publication year - 2014
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201400734
Subject(s) - surface charge , cytotoxicity , nanotechnology , charge (physics) , nanowire , membrane , materials science , apoptosis , chemistry , physics , biochemistry , particle physics , in vitro
Using distinct ZnO NW arrays to provide positively charged surface , charge effect on cytotoxicity is investigated. 1‐D structure of ZnO NWs is the main factor leads to apoptosis accompanied by ROS enrichment and GSH depletion, and electrostatic interaction between positively charged ZnO NWs and negatively charged cells make important contribution to the degree of ZnO NW arrays damaging cell membrane.