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Single‐Nucleotide‐Resolution DNA Differentiation by Pattern Generation in Lipid Bilayer Membranes
Author(s) -
Priegue Juan M.,
Montenegro Javier,
Granja Juan R.
Publication year - 2014
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201400684
Subject(s) - lipid bilayer , polymer , bilayer , dna , membrane , resolution (logic) , materials science , nanotechnology , nucleotide , biophysics , chemistry , biochemistry , biology , gene , computer science , artificial intelligence , composite material
Pattern generation/recognition in lipid bilayers is introduced for the differentiation of anionic biological relevant polymers. The amplification of the polymer differences during transport events allows the straightforward identification of a wide range collection of anionic polymers. The introduced approach displays excellent resolution even for single mutations in short single‐stranded oligonuclotides.