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Blood‐Brain Barrier Permeable Gold Nanoparticles: An Efficient Delivery Platform for Enhanced Malignant Glioma Therapy and Imaging
Author(s) -
Cheng Yu,
Dai Qing,
Morshed Ramin A.,
Fan Xiaobing,
Wegscheid Michelle L.,
Wainwright Derek A.,
Han Yu,
Zhang Lingjiao,
Auffinger Brenda,
Tobias Alex L.,
Rincón Esther,
Thaci Bart,
Ahmed Atique U.,
Warnke Peter C.,
He Chuan,
Lesniak Maciej S.
Publication year - 2014
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201400654
Subject(s) - blood–brain barrier , glioma , doxorubicin , drug delivery , cancer research , colloidal gold , brain tumor , medicine , nanoparticle , materials science , biomedical engineering , chemistry , nanotechnology , chemotherapy , pathology , central nervous system
The blood‐brain barrier (BBB) remains a formidable obstacle in medicine, preventing efficient penetration of chemotherapeutic and diagnostic agents to malignant gliomas. Here, a transactivator of transcription (TAT) peptide‐modified gold nanoparticle platform (TAT‐Au NP) with a 5 nm core size is demonstrated to be capable of crossing the BBB efficiently and delivering cargoes such as the anticancer drug doxorubicin (Dox) and Gd 3+ contrast agents to brain tumor tissues. Treatment of mice bearing intracranial glioma xenografts with pH‐sensitive Dox‐conjugated TAT‐Au NPs via a single intravenous administration leads to significant survival benefit when compared to the free Dox. Furthermore, it is demonstrated that TAT‐Au NPs are capable of delivering Gd 3+ chelates for enhanced brain tumor imaging with a prolonged retention time of Gd 3+ when compared to the free Gd 3+ chelates. Collectively, these results show promising applications of the TAT‐Au NPs for enhanced malignant brain tumor therapy and non‐invasive imaging.