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Engineering Enzyme‐Cleavable Hybrid Click Capsules with a pH‐Sheddable Coating for Intracellular Degradation
Author(s) -
Gunawan Sylvia T.,
Liang Kang,
Such Georgina K.,
Johnston Angus P. R.,
Leung Melissa K. M.,
Cui Jiwei,
Caruso Frank
Publication year - 2014
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201400450
Subject(s) - degradation (telecommunications) , coating , hydrolytic degradation , click chemistry , internalization , layer (electronics) , enzyme , chemistry , computer science , materials science , nanotechnology , hydrolysis , cell , biochemistry , combinatorial chemistry , telecommunications
The engineering of layer‐by‐layer (LbL) hybrid click capsules that are responsive to biological stimuli is reported. The capsules comprise a pH‐sheddable, non cross‐linked outer coating that protects enzyme‐cleavable inner layers. Upon cellular uptake, the outer coating is released and the capsules are enzymatically degraded. In vitro cell degradation results in rapid capsule degradation (10 min) upon cellular internalization.