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Two‐Photon‐Triggered Drug Delivery via Fluorescent Nanovalves
Author(s) -
Croissant Jonas,
Chaix Arnaud,
Mongin Olivier,
Wang Miao,
Clément Sébastien,
Raehm Laurence,
Durand JeanOlivier,
Hugues Vincent,
BlanchardDesce Mireille,
Maynadier Marie,
Gallud Audrey,
GaryBobo Magali,
Garcia Marcel,
Lu Jie,
Tamanoi Fuyuhiko,
Ferris Daniel P.,
Tarn Derrick,
Zink Jeffrey I.
Publication year - 2014
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201400042
Subject(s) - fluorescence , fluorophore , förster resonance energy transfer , two photon excitation microscopy , moiety , nanoparticle , drug delivery , mesoporous silica , materials science , biophysics , absorption (acoustics) , azobenzene , nanotechnology , chemistry , photochemistry , mesoporous material , stereochemistry , polymer , organic chemistry , optics , physics , composite material , biology , catalysis
Mesoporous silica nanoparticles (MSN) are functionalized in the walls with an original fluorophore with a high two‐photon absorption cross‐section. The pores of the MSN filled with anticancer drug are blocked with a pseudo‐rotaxane constituted by an azobenzene stalk and a β‐cyclodextrin moiety. After incubation of the nanosystem with MCF‐7 breast cancer cells, two‐photon irradiation at low power is used to image the cells. At high power, cancer cell killing is observed due to the two‐photon‐triggered opening of the pores through FRET and the release of the anticancer drug from the MSN.