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Drug Delivery: Multifunctional Upconversion Mesoporous Silica Nanostructures for Dual Modal Imaging and In Vivo Drug Delivery (Small 24/2013)
Author(s) -
Li Chunxia,
Yang Dongmei,
Ma Ping'an,
Chen Yinyin,
Wu Yuan,
Hou Zhiyou,
Dai Yunlu,
Zhao Jihong,
Sui Changping,
Lin Jun
Publication year - 2013
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201370154
Subject(s) - nanocarriers , materials science , drug delivery , mesoporous silica , ethylene glycol , nanotechnology , magnetic resonance imaging , photon upconversion , surface modification , in vivo , mesoporous material , nanostructure , luminescence , chemical engineering , chemistry , optoelectronics , organic chemistry , medicine , microbiology and biotechnology , biology , engineering , radiology , catalysis
Incorporating the agents for magnetic resonance imaging (MRI), optical imaging and therapy in one nanostructured matrix to construct a multifunctional nanomedical platform has attracted great attention for simultaneous diagnostic and therapeutic applications. A facile methodology is reported on page 4150 by J. Lin and co‐workers to construct a multifunctional nanocarrier composed of individual luminescent/magnetic β‐NaYF 4 :Yb 3+ , Er 3+ @β‐NaGdF 4 :Yb 3+ directly coated with mesoporous silica, followed by functionalization with poly(ethylene glycol), which can act as an effective platform for upconversion luminescence and magnetic resonance dual‐modal imaging and in vivo anticancer drug delivery.