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Nanowires: Fibroblasts Cultured on Nanowires Exhibit Low Motility, Impaired Cell Division, and DNA Damage (Small 23/2013)
Author(s) -
Persson Henrik,
Købler Carsten,
Mølhave Kristian,
Samuelson Lars,
Tegenfeldt Jonas O.,
Oredsson Stina,
Prinz Christelle N.
Publication year - 2013
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201370141
Subject(s) - motility , microbiology and biotechnology , cell division , nanowire , substrate (aquarium) , cell , biophysics , cell culture , function (biology) , dna , chemistry , materials science , nanotechnology , biology , biochemistry , genetics , ecology
Mouse fibroblasts cultured on 7‐μm‐long vertical nanowires are reported on page 4006 by C. N. Prinz and co‐workers. Culturing cells on this kind of substrate interferes greatly with cell function, causing the cells to develop into widely different morphologies. The cells' division is impaired, in many cases leading to large multinuclear cells. Cell motility is also impeded, something the large cluster surrounded by unoccupied substrate bears witness to for this otherwise motile cell line.