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Cell Fusion: Optically Induced Cell Fusion Using Bispecific Nanoparticles (Small 22/2013)
Author(s) -
YeheskelyHayon Daniella,
Minai Limor,
Golan Lior,
Dann Eldad J.,
Yelin Dvir
Publication year - 2013
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201370140
Subject(s) - fusion , materials science , cell fusion , femtosecond , population , laser , colloidal gold , nanoparticle , cell , nanotechnology , optics , chemistry , medicine , physics , biochemistry , philosophy , linguistics , environmental health
The image shows a high magnification scanning electron microscopy image of a dendritic (false color blue) and malignant B (false color green) cell pair coupled by bispecific gold nanoparticles. As described on page 3771 by D. Yeheskely‐Hayon and co‐workers, the cell pairs are irradiated by a sequence of femtosecond laser pulses, resulting in a wide‐spread fusion and subsequent formation of dendritic‐B cell hybrids, which could be used for stimulating the immune system to eliminate tumor cells. This novel approach for selective induction of cell fusion using bispecific nanoparticles and laser pulses could be useful for a variety of applications that call for selective fusion between cells within a large heterogenic cell population.