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Pharmacokinetics: Nanoparticle Accumulation in Angiogenic Tissues: Towards Predictable Pharmacokinetics (Small 18/2013)
Author(s) -
Yaehne Kristin,
Tekrony Amy,
Clancy Aisling,
Gregoriou Yiota,
Walker John,
Dean Kwin,
Nguyen Trinh,
Doiron Amber,
Rinker Kristina,
Jiang Xiao Yu,
Childs Sarah,
Cramb David
Publication year - 2013
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201370106
Subject(s) - nanoparticle , pharmacokinetics , materials science , biophysics , mechanism (biology) , nanotechnology , pharmacology , medicine , biology , philosophy , epistemology
D. Cramb* and co‐workers report on page 3118 that nanoparticles circulating in angiogenic tissue partition into surrounding tissues through fenestrations in the blood vessel walls, depending on the nanoparticle properties. The dependence of the portioning rate on nanoparticle size suggests that the mechanism is largely controlled by geometry and that the angiogenic blood vessels function like a size exclusion filter. This work provides insight into the mechanism of nanoparticle deposition into angiogenic tissues while also presenting a new biological model that can accelerate our understanding of nanoparticle toxicity and tumor targeting.