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DNA Release: Sharpening the Thermal Release of DNA from Nanoparticles: Towards a Sequential Release Strategy (Small 17/2013)
Author(s) -
Díaz Julián A.,
GibbsDavis Julianne M.
Publication year - 2013
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201370098
Subject(s) - nanoparticle , dna , colloidal gold , photothermal therapy , materials science , dissociation (chemistry) , thermal stability , nanotechnology , chemical engineering , biophysics , chemistry , organic chemistry , biochemistry , biology , engineering
Two branched DNA structures with different stabilities are hybridized with DNA‐modified gold nanoparticles. As J. A. Díaz and J. M. Gibbs‐Davis report on page 2862 , in contrast to linear DNA, these branched DNA structures dissociate over a narrow temperature window. Consequently, the less stable structure can be liberated from the surface of the gold nanoparticles, without dissociating the more stable branched DNA. With further heating this second structure can then be dissociated. Achieving such sharp thermal dissociation behavior of DNA from the surface of nanoparticles may find use in photothermal therapy or other applications where the sequential release of multiple DNA agents is required.