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Drug Delivery: Photosensitizer‐Incorporated Quadruplex DNA‐Gated Nanovechicles for Light‐Triggered, Targeted Dual Drug Delivery to Cancer Cells (Small 16/2013)
Author(s) -
Chen Cuie,
Zhou Li,
Geng Jie,
Ren Jinsong,
Qu Xiaogang
Publication year - 2013
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201370091
Subject(s) - photosensitizer , photodynamic therapy , drug delivery , drug , mesoporous silica , chemistry , cancer cell , targeted drug delivery , dna , biophysics , nanotechnology , cancer , materials science , pharmacology , mesoporous material , photochemistry , biochemistry , medicine , biology , catalysis , organic chemistry
A light‐operated vehicle for targeted intracellular drug delivery has been constructed by J. Ren, X. Qu, and co‐workers using photosensitizer‐incorporated G‐quadruplex DNAcapped mesoporous silica nanoparticles. Upon light irradiation, the photosensitizer generates reactive oxygen species, causing the DNA capping to be cleaved and allowing the cargo (drugs) to be released. This platform, described in detail on page 2793 , makes it possible to develop a drug‐carrier system for a synergistic combination of chemotherapy and photodynamic therapy for the treatment of cancer with a high spatial/temporal control.