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DNA Detection: A Molecular Beacon‐Based Signal‐Off Surface‐Enhanced Raman Scattering Strategy for Highly Sensitive, Reproducible, and Multiplexed DNA Detection (Small 15/2013)
Author(s) -
Wei Xinpan,
Su Shao,
Guo Yuanyuan,
Jiang Xiangxu,
Zhong Yiling,
Su Yuanyuan,
Fan Chunhai,
Lee ShuitTong,
He Yao
Publication year - 2013
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201370086
Subject(s) - molecular beacon , multiplexing , signal (programming language) , raman scattering , oligonucleotide , materials science , nanotechnology , dna , raman spectroscopy , computer science , optics , chemistry , physics , telecommunications , programming language , biochemistry
A molecular beacon‐based signal‐off SERS strategy is developed by Y. He and co‐workers on page 2493 , who employ stem–loop oligonucleotides as novel capture and reporter probes. This signal‐off strategy exhibits excellent sensitivity, specificity, reproducibility, and adequate multiplexing capacity, opening up exciting opportunities towards practical SERS‐relevant sensing applications. The cover image shows that DNA strands are readily detected via observing an effective signal switch from an ‘on’ (left) to an ‘off’ (right) state.