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Gold Nanodots: In vivo Metabolic Imaging of Insulin with Multiphoton Fluorescence of Human Insulin–Au Nanodots (Small 12/2013)
Author(s) -
Liu ChienLiang,
Liu TzuMing,
Hsieh TsungYuan,
Liu HanWen,
Chen YuShing,
Tsai ChengKun,
Chen HsiehChih,
Lin JongWei,
Hsu RonBin,
Wang TzungDau,
Chen ChienCheng,
Sun ChiKuang,
Chou PiTai
Publication year - 2013
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201370071
Subject(s) - nanodot , insulin , in vivo , diabetes mellitus , materials science , medicine , biophysics , chemistry , endocrinology , biology , nanotechnology , microbiology and biotechnology
In vivo imaging of insulin metabolism is realized by T.‐M. Liu, P.‐T. Chou and co‐workers using synthesized human insulin–Au nanodots (NDs). Benefiting from its efficient red to near infrared emission, deep tissue subcellular uptake of insulin–Au NDs can be evaluated with a nonlinear optical microscope. On page 2103 , insulin‐Au NDs permeate into lipid droplets (LDs) of adipocytes, and enlarged ones in type II diabetes mice have a higher adjacent/LD concentration contrast. Human clinical samples show similar trends in patients with diabetes and coronary artery diseas