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Nanoparticles: Trapping and Photoacoustic Detection of CTCs at the Single Cell per Milliliter Level with Magneto‐Optical Coupled Nanoparticles (Small 12/2013)
Author(s) -
Hu Xiaoge,
Wei ChenWei,
Xia Jinjun,
Pelivanov Ivan,
O'Donnell Matthew,
Gao Xiaohu
Publication year - 2013
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201370070
Subject(s) - nanoparticle , materials science , trapping , photoacoustic imaging in biomedicine , magnetic nanoparticles , nanotechnology , optical tweezers , microsphere , optoelectronics , optics , chemical engineering , biology , ecology , physics , engineering
Multifunctional nanoparticles with integrated magnetic, optical, and targeting properties enable simultaneous trapping and ultrasensitive detection of rare circulating tumor cells in blood vessels. On page 2046 , photoacoustic imaging shows how the nanoprobes detect the cells at the single‐cell‐per‐milliliter level, capturing two thirds of the labeled cells in just one pass. Compared to conventional in vitro assays, this technology has the potential to interrogate large sample volumes in a reasonable procedure time.