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Carbon Nanotubes: Short Multiwall Carbon Nanotubes Promote Neuronal Differentiation of PC12 Cells via Up‐Regulation of the Neurotrophin Signaling Pathway (Small 9–10/2013)
Author(s) -
Meng Li,
Chen Rui,
Jiang Aihua,
Wang Liming,
Wang Peng,
Li Chenzhong,
Bai Ru,
Zhao Yuliang,
Autrup Herman,
Chen Chunying
Publication year - 2013
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201370052
Subject(s) - neurite , exocytosis , carbon nanotube , microbiology and biotechnology , biocompatibility , neurotrophin , nanotechnology , biophysics , materials science , chemistry , in vitro , biochemistry , biology , receptor , membrane , organic chemistry
The front cover image for this special issue was provided by C. Chen and co‐workers. CNTs show good biocompatibility, and can be used to modulate neurite outgrowth in culture and in vivo. Positive effects such as promoting regeneration and differentiation can be initiated by up‐regulating cellular uptake and exocytosis. On page 1786 it is shown that shorter carboxyl‐terminated multiwall carbon nanotubes (MWCNTs) demonstrate higher cellular uptake by PC12 cells and more obvious exocytosis compared to longer ones. Incubation of PC12 cells with carboxylated MWCNTs does not affect cellular morphology or viability at lower concentrations.