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Drug Delivery: Shuttle‐Mediated Nanoparticle Delivery to the Blood–Brain Barrier (Small 6/2013)
Author(s) -
Guarnieri Daniela,
Falanga Annarita,
Muscetti Ornella,
Tarallo Rossella,
Fusco Sabato,
Galdiero Massimiliano,
Galdiero Stefania,
Netti Paolo A.
Publication year - 2013
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201370033
Subject(s) - blood–brain barrier , drug delivery , herpes simplex virus , drug , peptide , nanoparticle , nanotechnology , drug delivery to the brain , gene delivery , materials science , biophysics , virus , virology , pharmacology , chemistry , medicine , genetic enhancement , biology , biochemistry , central nervous system , neuroscience , gene
Viruses are formidable micromachines able to overcome potent physiological barriers and to penetrate deep inside our tissues. Following a bioinspired approach, S. Galdiero, P. A. Netti, and co‐workers created a novel class of nanoparticles able to cross the vascular brain endothelium membrane, obtained by decorating their surface with the membranotropic gH625 peptide sequence derived from the glycoprotein gH of Herpes simplex type 1 virus envelope. This promising strategy, described on page 853 , paves the way for designing delivery systems to improve administration of therapeutical compounds to the brain.