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Microfluidics: Three Dimensional, Sheathless, and High‐Throughput Microparticle Inertial Focusing Through Geometry‐Induced Secondary Flows (Small 5/2013)
Author(s) -
Chung Aram J.,
Gossett Daniel R.,
Di Carlo Dino
Publication year - 2013
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201370028
Subject(s) - microparticle , microfluidics , inertial frame of reference , throughput , nanotechnology , geometry , materials science , mechanics , optics , physics , computer science , classical mechanics , mathematics , telecommunications , wireless
The process of single‐stream microparticle inertial focusing in a single focal plane without sheath fluids and external forces, all in a high‐throughput manner, is described on page 685 by D. Di Carlo and co‐workers. The proposed design consists of a low‐aspect‐ratio straight channel interspersed with a series of constrictions in height arranged orthogonally, making use of two inertial effects: inertial microparticle focusing and geometry‐induced secondary flows. A focusing efficiency as high as 99.77% is demonstrated, with a throughput as high as 36 000 particles s −1 for a variety of different sized particles and cells. Cover illustration by Marc Lim.