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3D Cell Cultures: Nanostructured Superhydrophobic Substrates Trigger the Development of 3D Neuronal Networks (Small 3/2013)
Author(s) -
Limongi Tania,
Cesca Fabrizia,
Gentile Francesco,
Marotta Roberto,
Ruffilli Roberta,
Barberis Andrea,
Dal Maschio Marco,
Petrini Enrica Maria,
Santoriello Stefania,
Benfenati Fabio,
Di Fabrizio Enzo
Publication year - 2013
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201370016
Subject(s) - nanotechnology , materials science
On page 402 , E. Di Fabrizio and co‐workers describe the growth of neuron–astrocyte co‐cultures on nanostructured superhydrophobic substrates. The scanning electron microscopy image on the inside cover shows a flat glial cell monolayer (pink) suspended between adjacent nanostructured pillars. Astrocytes adhere with high affinity to both the top and lateral surface of the pillars and provide an excellent support for cocultured neurons, as shown by a large neuron (blue) spreading upon the glial carpet with its multiple neuritic processes.