Nanotopological Surfaces: Microfabricated Nanotopological Surfaces for Study of Adhesion‐Dependent Cell Mechanosensitivity (Small 1/2013) | Zendy

Chen Weiqiang | Zendy; Sun Yubing | Zendy; Fu Jianping | Zendy

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Nanotopological Surfaces: Microfabricated Nanotopological Surfaces for Study of Adhesion‐Dependent Cell Mechanosensitivity (Small 1/2013)

Author(s) -

Chen Weiqiang,

Sun Yubing,

Fu Jianping

Publication year - 2013

Publication title -

small

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.785

H-Index - 236

eISSN - 1613-6829

pISSN - 1613-6810

DOI - 10.1002/smll.201370001

Subject(s) - microfabrication , materials science , adhesion , cell adhesion , nanoscopic scale , nanotechnology , photolithography , scanning electron microscope , surface roughness , microfluidics , biophysics , composite material , biology , medicine , alternative medicine , pathology , fabrication

The cover shows a scanning electron microscopy image of adhesive cells on a nanotopographic surface. Nanoscale roughness can be precisely controlled and spatially patterned on glass surfaces with a microfabrication method using photolithography and reactive ion etching. This technique, described on page 81 , is used by J. Fu and co‐workers to understand adhesion‐dependent cell mechanosensitivity to nanotopological cues. Nanoscale topological features provide a potent regulatory signal over a diverse range of NIH/3T3 fibroblast behaviors, including cell morphology, adhesion, proliferation, and migration. The topological sensing of NIH/3T3 fibroblasts includes feedback regulation and mechanical‐biochemical integration.

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