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Overcoming Multidrug Resistance in Microbials Using Nanostructures Self‐Assembled from Cationic Bent‐Core Oligomers
Author(s) -
Liu Shao Qiong,
Venkataraman Shrinivas,
Ong Zhan Yuin,
Chan Julian M. W.,
Yang Chuan,
Hedrick James L.,
Yang Yi Yan
Publication year - 2014
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201303921
Subject(s) - cationic polymerization , supramolecular chemistry , nanostructure , multiple drug resistance , antimicrobial , combinatorial chemistry , materials science , molecule , nanotechnology , aqueous solution , chemistry , organic chemistry , polymer chemistry , antibiotics , biochemistry
Novel cationic molecules based on rigid terephthalamide‐bisurea cores flanked by imidazolium moieties are described. In aqueous media, these compounds self‐assemble into supramolecular nanostructures with distinct morphologies. The compound with optimal hydrophilic/hydrophobic balance displays potent antimicrobial activity and high selectivity towards clinically‐isolated MRSA without inducing drug‐resistance. These self‐assembled cationic antimicrobial nanostructures show promise for the prevention and treatment of multidrug‐resistant infections.