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Artificial Bacterial Flagella for Remote‐Controlled Targeted Single‐Cell Drug Delivery
Author(s) -
Mhanna Rami,
Qiu Famin,
Zhang Li,
Ding Yun,
Sugihara Kaori,
ZenobiWong Marcy,
Nelson Bradley J.
Publication year - 2014
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201303538
Subject(s) - liposome , flagellum , drug delivery , micrometer , nanotechnology , materials science , targeted drug delivery , cell , magnetotactic bacteria , drug , biophysics , biomedical engineering , chemistry , biochemistry , biology , engineering , mechanical engineering , pharmacology , magnetite , metallurgy , gene
An approach for batch preparation of liposome‐functionalized microdevices is demonstrated for remotely controlled single‐cell drug delivery. The liposome functionalized artificial bacterial flagella exhibit corkscrew swimming in 3D with micrometer positioning precision by applying an external rotating magnetic field. The devices are also capable of delivering water‐soluble drugs to single cells in vitro.