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Magneto‐Plasmonic Au‐Fe Alloy Nanoparticles Designed for Multimodal SERS‐MRI‐CT Imaging
Author(s) -
Amendola Vincenzo,
Scaramuzza Stefano,
Litti Lucio,
Meneghetti Moreno,
Zuccolotto Gaia,
Rosato Antonio,
Nicolato Elena,
Marzola Pasquina,
Fracasso Giulio,
Anselmi Cristina,
Pinto Marcella,
Colombatti Marco
Publication year - 2014
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201303372
Subject(s) - materials science , magnetic resonance imaging , biocompatibility , nanotechnology , image resolution , raman scattering , biomedical engineering , nanoparticle , medical imaging , molecular imaging , preclinical imaging , in vivo , raman spectroscopy , computer science , radiology , optics , medicine , artificial intelligence , physics , microbiology and biotechnology , biology , metallurgy
Diagnostic approaches based on multimodal imaging are needed for accurate selection of the therapeutic regimens in several diseases, although the dose of administered contrast drugs must be reduced to minimize side effects. Therefore, large efforts are deployed in the development of multimodal contrast agents (MCAs) that permit the complementary visualization of the same diseased area with different sensitivity and different spatial resolution by applying multiple diagnostic techniques. Ideally, MCAs should also allow imaging of diseased tissues with high spatial resolution during surgical interventions. Here a new system based on multifunctional Au‐Fe alloy nanoparticles designed to satisfy the main requirements of an ideal MCA is reported and their biocompatibility and imaging capability are described. The MCAs show easy and versatile surface conjugation with thiolated molecules, magnetic resonance imaging (MRI) and computed X‐ray tomography (CT) signals for anatomical and physiological information (i.e., diagnostic and prognostic imaging), large Raman signals amplified by surface enhanced Raman scattering (SERS) for high sensitivity and high resolution intrasurgical imaging, biocompatibility, exploitability for in vivo use and capability of selective accumulation in tumors by enhanced permeability and retention effect. Taken together, these results show that Au‐Fe nanoalloys are excellent candidates as multimodal MRI‐CT‐SERS imaging agents.