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Near Infrared Light‐Triggered Drug Generation and Release from Gold Nanoparticle Carriers for Photodynamic Therapy
Author(s) -
Cheng Yu,
Doane Tennyson L.,
Chuang ChiHung,
Ziady Assem,
Burda Clemens
Publication year - 2014
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201303329
Subject(s) - covalent bond , photodynamic therapy , conjugate , nanoparticle , colloidal gold , mass spectrometry , drug delivery , photochemistry , photosensitizer , chemistry , drug carrier , combinatorial chemistry , materials science , nanotechnology , chromatography , organic chemistry , mathematical analysis , mathematics
A photoprecursor Pc 227 is covalently bound onto gold nanoparticles (Au NPs) to produce the known photodynamic therapy (PDT) drug Pc 4 upon 660 nm photoirradiation. The photochemical formation of the photoproduct Pc 4 is identified by spectroscopy, chromatography, and mass spectrometry and its PDT efficacy is equal to Pc 4 when administered non‐covalently by Au NPs, with the added benefit of improved covalent delivery and targeted NIR‐triggered release from the covalent Pc 227‐Au NP conjugate, while during transport the attached Pc 227 is quenched by the Au NP and PDT inactivated.