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Programmed Degradation of DNA Multilayer Films
Author(s) -
Lee Lillian,
Johnston Angus P. R.,
Caruso Frank
Publication year - 2014
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201303321
Subject(s) - dna , degradation (telecommunications) , materials science , nanotechnology , planar , biosensor , layer (electronics) , drug delivery , chemistry , computer science , telecommunications , biochemistry , computer graphics (images)
The design and assembly of DNA multilayer films with programmable degradation properties are reported. The nanostructured DNA films are assembled through the layer‐by‐layer (LbL) assembly technique and can be programmed to degrade by subsequently introducing DNA strands of specific sequences. The strands preferentially hybridize to the building blocks that stabilize the film structure, causing the film to rearrange and degrade. The rate of degradation is influenced by both the availability and accessibility of the complementary DNA binding sites within the film, as well as the degree of crosslinking within the film. Similar results are obtained for DNA multilayer films assembled on planar and particle supports. This approach offers an avenue to tailor degradability features into DNA‐based materials that may find application in the biosciences, in areas such as biosensing and drug delivery.