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Graphite Oxide Nanoparticles with Diameter Greater than 20 nm Are Biocompatible with Mouse Embryonic Stem Cells and Can Be Used in a Tissue Engineering System
Author(s) -
Wang INing E.,
Robinson Joshua T.,
Do Grace,
Hong Guosong,
Gould Danny R.,
Dai Hongjie,
Yang Phillip C.
Publication year - 2014
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201303133
Subject(s) - embryonic stem cell , biocompatible material , stem cell , materials science , graphite , graphite oxide , oxide , toxicity , tissue engineering , nanoparticle , nanotechnology , nanotoxicology , biophysics , cytotoxicity , biomedical engineering , in vitro , chemistry , microbiology and biotechnology , biochemistry , composite material , biology , medicine , organic chemistry , metallurgy , gene
Graphite oxide sheets demonstrate size‐dependent uptake and toxicity towards embryonic stem cells . Graphite oxide sheets larger than 20 nm are biocompatible and can be safely used with mouse embryonic stem cells, while graphite oxide sheets smaller than 20 nm in diameter reduced cell proliferation and increased cell toxicity.