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Polyarginine Induces an Antitumor Immune Response through Binding to Toll‐Like Receptor 4
Author(s) -
Yang Yong,
Wolfram Joy,
Fang Xiaohong,
Shen Haifa,
Ferrari Mauro
Publication year - 2014
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201302887
Subject(s) - nanomedicine , toll , medicine , library science , chemistry , nanotechnology , computer science , immunology , materials science , nanoparticle
A novel function of polyarginine as an activator of the immune system is reported. Single‐molecule fluorescence imaging and single‐molecule force measurements demonstrate that polyarginine binds specifically to the toll‐like receptor 4 (TLR4), inducing receptor dimerization and activation. Moreover, polyarginine induced immune activation inhibits tumor growth. These results suggest the potential use of polyarginine for cancer immunotherapy.