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A Poly(lactide) Stereocomplex Structure with Modified Magnesium Oxide and Its Effects in Enhancing the Mechanical Properties and Suppressing Inflammation
Author(s) -
Kum Chang Hun,
Cho Youngjin,
Seo Seong Ho,
Joung Yoon Ki,
Ahn Dong June,
Han Dong Keun
Publication year - 2014
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201302880
Subject(s) - materials science , magnesium , lactide , ultimate tensile strength , polymer , chemical engineering , biodegradable polymer , hydroxide , composite number , composite material , polymerization , engineering , metallurgy
Biodegradable polymers such as poly( l ‐lactide) (PLLA) have been widely utilized as materials for biomedical applications. However, the relatively poor mechanical properties of PLLA and its acid‐induced cell inflammation brought about by the acidic byproducts during biodegradation pose severe problems. In this study, these drawbacks of PLLA are addressed using a stereocomplex structure, where oligo‐ d ‐lactide‐grafted magnesium hydroxide (MgO‐ODLA) is synthesized by grafting d ‐lactide onto the surface of magnesium hydroxide, which is then blended with a PLLA film. The structure, morphology, pH change, thermal and mechanical properties, in‐vitro cytotoxicity, and inflammation effect of the MgO‐ODLAs and their PLLA composites are evaluated through various analyses. The PLLA/MgO70‐ODLA30 (0–20 wt%) composite with a stereocomplex structure shows a 20% increase in its tensile strength and an improvement in the modulus compared to its oligo‐ l ‐lactide (PLLA/MgO70‐OLLA30) counterpart. The interfacial interaction parameter of PLLA/MgO70‐ODLA30 (5.459) has superior properties to those of PLLA/MgO70‐OLLA30 (4.013) and PLLA/Mg(OH) 2 (1.774). The cell cytotoxicity and acid‐induced inflammatory response are suppressed by the neutralizing effect of the MgO‐ODLAs. In addition, the inflammatory problem caused by the rapid acidification of the stereocomplex structure is also addressed. As a result, the stereocomplex structure of the MgO‐ODLA/PLLA composite can be used to overcome the problems associated with the biomedical applications of PLLA films.