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Self‐Reporting Liposomes for Intracellular Drug Release
Author(s) -
Chen Wansong,
Huang Qiyu,
Ou Weizhu,
Hao Yuanqiang,
Wang Liqiang,
Zeng Ke,
Guo Hongyan,
Li Juan,
Liu YouNian
Publication year - 2014
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201302698
Subject(s) - liposome , intracellular , fluorescence , bioavailability , drug delivery , drug , computer science , chemistry , biophysics , nanotechnology , combinatorial chemistry , materials science , pharmacology , biochemistry , biology , physics , quantum mechanics
A new liposomal carrier embedded with a ratiometric fluorescent probe PNO is prepared. The integrated liposomes (PNO‐LIPs) exhibit blue fluorescence in serum. Triggered by the thiols exogenously or endogenously, PNO‐LIPs collapse with a burst drug release and a concurrent fluorescence change from blue to green. Furthermore, DOX‐loaded PNO‐LIPs improve the intracellular drug bioavailability.