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Mechanisms of Antibacterial Activity of MgO: Non‐ROS Mediated Toxicity of MgO Nanoparticles Towards Escherichia coli
Author(s) -
Leung Yu Hang,
Ng Alan M. C.,
Xu Xiaoying,
Shen Zhiyong,
Gethings Lee A.,
Wong Mabel Ting,
Chan Charis M. N.,
Guo Mu Yao,
Ng Yip Hang,
Djurišić Aleksandra B.,
Lee Patrick K. H.,
Chan Wai Kin,
Yu Li Hong,
Phillips David Lee,
Ma Angel P. Y.,
Leung Frederick C. C.
Publication year - 2014
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201302434
Subject(s) - reactive oxygen species , toxicity , escherichia coli , nanomaterials , oxidative stress , nanotoxicology , chemistry , lipid peroxidation , nanoparticle , antimicrobial , metal toxicity , antibacterial activity , metal , biophysics , nanotechnology , biochemistry , bacteria , materials science , biology , organic chemistry , gene , genetics
The toxicity of metal oxide nanomaterials and their antimicrobial activity is attracting increasing attention. Among these materials, MgO is particularly interesting as a low cost, environmentally‐friendly material. The toxicity of MgO, similar to other metal oxide nanomaterials, is commonly attributed to the production of reactive oxygen species (ROS). We investigated the toxicity of three different MgO nanoparticle samples, and clearly demonstrated robust toxicity towards Escherichia coli bacterial cells in the absence of ROS production for two MgO nanoparticle samples. Proteomics data also clearly demonstrate the absence of oxidative stress and indicate that the primary mechanism of cell death is related to the cell membrane damage, which does not appear to be due to lipid peroxidation.