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Introducing MINA – The Molecularly Imprinted Nanoparticle Assay
Author(s) -
Shutov Roman V.,
Guerreiro Antonio,
Moczko Ewa,
de VargasSansalvador Isabel Perez,
Chianella Iva,
Whitcombe Michael J.,
Piletsky Sergey A.
Publication year - 2014
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201301996
Subject(s) - nanoparticle , biomolecule , computer science , nanotechnology , computational biology , molecular imprinting , molecularly imprinted polymer , chemistry , combinatorial chemistry , world wide web , materials science , catalysis , biology , biochemistry , selectivity
A new ELISA‐ (enzyme‐linked immunosorbent assay)‐like assay is demonstrated in which no elements of biological origin are used for molecular recognition or signaling. Composite imprinted nanoparticles that contain a catalytic core and which are synthesized by using a solid‐phase approach can simultaneously act as recognition/signaling elements, and be used with minimal modifications to standard assay protocols. This assay provides a new route towards replacement of unstable biomolecules in immunoassays.