Introducing MINA – The Molecularly Imprinted Nanoparticle Assay | Zendy

Shutov Roman V. | Zendy; Guerreiro Antonio | Zendy; Moczko Ewa | Zendy; de VargasSansalvador Isabel Perez | Zendy; Chianella Iva | Zendy; Whitcombe Michael J. | Zendy; Piletsky Sergey A. | Zendy

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Introducing MINA – The Molecularly Imprinted Nanoparticle Assay

Author(s) -

Shutov Roman V.,

Guerreiro Antonio,

Moczko Ewa,

de VargasSansalvador Isabel Perez,

Chianella Iva,

Whitcombe Michael J.,

Piletsky Sergey A.

Publication year - 2014

Publication title -

small

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.785

H-Index - 236

eISSN - 1613-6829

pISSN - 1613-6810

DOI - 10.1002/smll.201301996

Subject(s) - nanoparticle , biomolecule , computer science , nanotechnology , computational biology , molecular imprinting , molecularly imprinted polymer , chemistry , combinatorial chemistry , world wide web , materials science , catalysis , biology , biochemistry , selectivity

A new ELISA‐ (enzyme‐linked immunosorbent assay)‐like assay is demonstrated in which no elements of biological origin are used for molecular recognition or signaling. Composite imprinted nanoparticles that contain a catalytic core and which are synthesized by using a solid‐phase approach can simultaneously act as recognition/signaling elements, and be used with minimal modifications to standard assay protocols. This assay provides a new route towards replacement of unstable biomolecules in immunoassays.

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