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Slowing Down DNA Translocation Through Solid‐State Nanopores by Pressure
Author(s) -
Zhang Hengbin,
Zhao Qing,
Tang Zhipeng,
Liu Song,
Li Qingtao,
Fan Zhongchao,
Yang Fuhua,
You Liping,
Li Xuemei,
Zhang Jingmin,
Yu Dapeng
Publication year - 2013
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201301263
Subject(s) - nanopore , chromosomal translocation , dna , materials science , solid state , nanopore sequencing , nanotechnology , biophysics , molecule , chemical physics , chemistry , biology , dna sequencing , biochemistry , gene , organic chemistry
The effect of applied pressure on event duration distributions in 3 kb dsDNA translocation is systematically investigated. The effects of pressure magnitude and nanopore size on the length discrimination between 615 bp and 1.14 kbp dsDNA is studied. The pressure‐controlled DNA translocation in solid‐state nanopores makes a significant contribution to improve the temporal resolution in DNA single‐molecule detection.